Pancreatic neuroendocrine tumors. Prognostic factors

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Update on prognostic and predictive biomarkers for pancreatic neuroendocrine tumors.

Neuroendocrine tumors (NETs) describe a heterogeneous group of tumors with a wide range of morphologic, functional, and behavioral characteristics. These tumors are often indolent but they have the potential to cause symptoms through release of hormones and through local or distant spread. Pancreatic neuroendocrine tumors (pNET) represent a subset of NETs and they have a unique pattern of sympt...

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Pancreatic Neuroendocrine Tumors

Pancreatic neuroendocrine tumors are usually indolent (slow-growing) by nature and develop over the course of many years. Pancreatic neuroendocrine tumors are usually more indolent, with better prognosis than adenocarcinoma of the pancreas (Carriaga & Henson, 1995). However, aggressive, fast growing pancreatic neuroendocrine tumors exist and different types of pancreatic neuroendocrine tumors e...

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Prognostic Factors and Characteristics of Pancreatic Neuroendocrine Tumors: Single Center Experience

PURPOSE Pancreatic neuroendocrine tumors (PNET) are a rare subgroup of tumors. For PNETs, the predictive factors for survival and prognosis are not well known. The purpose of our study was to evaluate the predictive factors for survival and disease progression in PNETs. MATERIALS AND METHODS We retrospectively analyzed 37 patients who were diagnosed with PNET at Severance Hospital between Nov...

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MEN1-associated pancreatic neuroendocrine tumors (pNETs) may potentially express distinct hormones, but the mechanism has not been elucidated. Transcription factors such as MafA and Pdx1 have been identified to lead to beta cell differentiation, while Arx and Brn4 to alpha cell differentiation in developing pancreas. We hypothesized those transcription factors are important to produce specific ...

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ژورنال

عنوان ژورنال: Revista Española de Enfermedades Digestivas

سال: 2017

ISSN: 1130-0108

DOI: 10.17235/reed.2017.5109/2017